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held unpatentable a process of performing a clinical test and, based on the data from 
that test, determining if an abnormality existed and possible causes of any abnormality.  
888 F.2d at 837, 841.  We rejected the claim because it was merely an algorithm 
combined with a data-gathering step.  Id. at 839-41.  We note that, at least in most 
cases, gathering data would not constitute a transformation of any article.  A 
requirement simply that data inputs be gathered—without specifying how—is a 
meaningless limit on a claim to an algorithm because every algorithm inherently 
requires the gathering of data inputs.  Grams, 888 F.2d at 839-40.  Further, the inherent 
step of gathering data can also fairly be characterized as insignificant extra-solution 
activity.  See Flook, 437 U.S. at 590. 
Similarly, In re Schrader presented claims directed to a method of conducting an 
auction of multiple items in which the winning bids were selected in a manner that 
maximized the total price of all the items (rather than to the highest individual bid for 
each item separately).  22 F.3d 290, 291 (Fed. Cir. 1994).  We held the claims to be 
drawn to unpatentable subject matter, namely a mathematical optimization algorithm.  
Id. at 293-94.  No specific machine or apparatus was recited.  The claimed method did 
require a step of recording the bids on each item, though no particular manner of 
recording (e.g., on paper, on a computer) was specified.  Id.  But, relying on Flook, we 
held that this step constituted insignificant extra-solution activity.  Id. at 294.   
IV. 
 
We now turn to the facts of this case.  As outlined above, the operative question 
before this court is whether Applicants' claim 1 satisfies the transformation branch of the 
machine-or-transformation test.   
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