●● IRC: #techbytes @ Techrights IRC Network: Friday, January 24, 2025 ●● ● Jan 24 [02:18] schestowitz[TR2] http://ipkitten.blogspot.com/2025/01/plausibility-as-moving-target-phase-iii.html?showComment=1737549339732#c6454793704304202719 [02:18] schestowitz[TR2] "Thank you for this summary of this interesting decision. May I correct one point? The Board did not hold that the disclosure of the patent monopoly was plausible. They started from an assumption that the OD was correct to hold this, but in light of the Board's finding that the phase III data rendered the disclosure of the patent monopoly insufficient, they did not need to decide this. See paragraph 7 of the reasons:

"In view of the small number of patients, the opponent considered that a treatment effect had not been demonstrated. The board, however, does not deem it necessary to establish this and instead starts from the assumption that the opposition division was correct in finding that the experimental data provided in the patent monopoly (see above), together with the mechanistic explanation provided in paragraphs [0032] to [0039] a [02:18] schestowitz[TR2] nd Figure 1, made it plausible (or credible) to the skilled person at the time of filing that a therapeutic effect on AMR could be achieved; however, this in itself is not enough to demonstrate that the invention is sufficiently disclosed if the opponent provides evidence which raises serious doubts that the
therapeutic effect can indeed be achieved (see below)."

There was much discussion in the proceedings of [02:18] schestowitz[TR2] initial plausibility, as well as reproducibility.

The facts of this case are unusual, in that the phase III trial used exactly the same dosage regimen as the phase II trial reported in the patent. The lack of reproducibility even using the exemplified dosage regimen may have formed an important aspect of the Board's reasoning, as reflected in paragraph 13 of the reasons, which you cite.

The Opponent argued [02:18] schestowitz[TR2] that it must always be possible for third parties to invalidate a patent monopoly for insufficiency by showing that the disclosure is not reproducible, and that second medical use claims should not be treated any differently in this respect." [02:18] -TechBytesBot/#techbytes-ipkitten.blogspot.com | Plausibility as a moving target: Phase III clinical trial results sink second medical use patent (T 0816/22) - The IPKat ● Jan 24 [03:34] *jacobk (~quassel@838aynky6btpe.irc) has joined #techbytes ● Jan 24 [04:44] *jacobk has quit (Ping timeout: 2m30s) ● Jan 24 [06:14] *jacobk (~quassel@x4xitd3kr8sr8.irc) has joined #techbytes [06:21] *jacobk has quit (Ping timeout: 2m30s) [06:57] *jacobk (~quassel@uznmz2pdb568g.irc) has joined #techbytes [06:57] *jacobk has quit (Quit: http://quassel-irc.org - Chat comfortably. Anywhere.) ● Jan 24 [07:09] *jacobk (~quassel@is7fsg6b3vcse.irc) has joined #techbytes [07:19] *jacobk has quit (Ping timeout: 2m30s) ● Jan 24 [08:49] *jacobk (~quassel@syp65ggum2ibk.irc) has joined #techbytes ● Jan 24 [09:02] *jacobk has quit (Ping timeout: 2m30s) [09:04] *jacobk (~quassel@syp65ggum2ibk.irc) has joined #techbytes [09:50] *newyear25 has quit (Connection closed) ● Jan 24 [10:16] *x-amarsh04 has quit (Quit: Konversation terminated!) [10:23] *x-amarsh04 (~amarsh04@yrifiesvn57du.irc) has joined #techbytes ● Jan 24 [11:54] schestowitz[TR2]
  • [11:54] schestowitz[TR2]
    Linux kernel 6.13 announced
    [11:54] schestowitz[TR2]
    [11:54] schestowitz[TR2]

    Head penguin herder Linus Torvalds announced Linux version 6.13 this week, and he's also chosen five lucky winners of guitar pedals. The KernelNewbies site has a full rundown of what's new, which, if we were a newbie, we feel would look pretty intimidating.

    [11:54] schestowitz[TR2]
    [11:54] schestowitz[TR2]
  • [11:54] schestowitz[TR2] [11:54] -TechBytesBot/#techbytes-www.theregister.com | Linux kernel 6.13 announced The Register ● Jan 24 [14:04] schestowitz[TR2]
  • [14:04] schestowitz[TR2]
    This modular server room is an interesting scale POC
    [14:04] schestowitz[TR2]
    [14:04] schestowitz[TR2]

    Server rooms are built for the comfort of servers not people. But those servers need maintenance, which means they need to be accessible. The resulting access corridors take up room that could be filled with more servers, which is why Jdw447 designed a claw machine-esque modular server room and built a working scale model to demonstrate the concept.

    [14:04] schestowitz[TR2]
    [14:04] schestowitz[TR2]
  • [14:04] -TechBytesBot/#techbytes-blog.arduino.cc | This modular server room is an interesting scale POC | Arduino Blog [14:52] schestowitz[TR2]
  • [14:52] schestowitz[TR2]
    Deepin Linux 25 Goes (Almost) Immutable
    [14:52] schestowitz[TR2]
    [14:52] schestowitz[TR2]

    The upcoming release of Deepin 25 is packed with exciting features (you can find more details here), but the real standout changes are happening behind the scenes. Namely, the distro is taking a bold step toward immutability.

    [14:52] schestowitz[TR2]

    However, its unique implementation sets Deepin apart from other distributions jumping on the immutability trend. The developers have added a clever twist: users can temporarily disable immutability when needed to make changes to the system.

    [14:52] schestowitz[TR2]
    [14:52] schestowitz[TR2]
  • [14:52] -TechBytesBot/#techbytes-linuxiac.com | Deepin Linux 25 Goes (Almost) Immutable ● Jan 24 [15:03] schestowitz[TR2]
  • [15:03] schestowitz[TR2]
    Bringing multiple windows to Flutter desktop apps
    [15:03] schestowitz[TR2]
    [15:03] schestowitz[TR2]

    Over the past 5 years, Canonical has been contributing to Flutter, including building out Linux support for Flutter applications, publishing libraries to help integrate into the Linux desktop and building modern applications for Ubuntu, including our software store. Last year we announced at the Ubuntu Summit that weve been working on bringing support for multiple windows to Flutter des [15:03] schestowitz[TR2] ktop apps.

    [15:03] schestowitz[TR2]
    [15:03] schestowitz[TR2]
  • [15:03] -TechBytesBot/#techbytes-Bringing multiple windows to Flutter desktop apps | Ubuntu ● Jan 24 [16:12] schestowitz[TR2]
  • Dictator Ending ICE Sensitive Locations Policy Forces Immigrants to Choose Between Health Care and Safety: PHR

    In response to the Convicted Felon administrations move to rescind the Immigration and Customs Enforcement (ICE) sensitive locations” po [16:12] schestowitz[TR2] licy, which prevents immigration enforcement actions in or around locations like hospitals, schools, or places of worship, the following quote is attributable to Katherine Peeler, MD, medical advisor at Physicians for Human Rights (PHR) and assistant professor [...]

  • [16:12] -TechBytesBot/#techbytes-phr.org | Trump Ending ICE Sensitive Locations" Policy Forces Immigrants to Choose Between Health Care and Safety: PHR - PHR [16:53] schestowitz[TR2] "I've been using DSL since it was the 50-meg version of itself. It's always worked like a charm, especially on really old PC's. It may be too "bare bones" for some people but it works. [16:53] schestowitz[TR2] Speaking of nostalgia, Scott, do you remember when Fedora/RedHat came on three 1.44 MB floppy disks? [16:53] schestowitz[TR2] I Do!! Back in the day I found an old PC with Windows 98 still on it and it had a floppy drive that I just HAD to use for something.. [16:53] schestowitz[TR2] Just getting it to read the disks was a chore LoL." [16:53] schestowitz[TR2] https://lxer.com/module/forums/t/36935/ [16:53] -TechBytesBot/#techbytes-LXer: I still like Damn Small Linux Myself: 5 lightweight Linux distributions that will bring your old PC back to life ● Jan 24 [19:41] *hawer (~newyear@freenode-drv.aab.2jssns.IP) has joined #techbytes ● Jan 24 [20:08] *psydroid2 has quit (Quit: KVIrc 5.2.6 Quasar http://www.kvirc.net/) [20:32] *newyear25 (~newyear@freenode-drv.aab.2jssns.IP) has joined #techbytes [20:34] *hawer has quit (Ping timeout: 120 seconds)